Wang Xi

Wang Xi

Professor

Doctoral Supervisor (Capital Medical University)

Master’s Supervisor (Capital Medical University)

Academic Appointments:

2023–Present: Chair, Infectious Diseases Specialty Committee, Beijing Research Association for Chronic Disease Control and Health Education

2023–Present: Standing Committee Member, Division of Basic Immunology, Chinese Society for Immunology

2022–Present: Chair, Convention and Exhibition Epidemic Prevention Committee, China Convention/Exhibition/Event Society

2022–Present: Vice Chair, Infection Specialty Committee, Beijing Association of the Integrating of Traditional and Western Medicine

2020–Present: Standing Committee Member, Urological and Male Reproductive System Oncology Specialty Committee, China Association for Promotion of Health Science and Technology

2019–Present: Standing Council Member, Beijing Society of Immunology

2018–Present: Vice Chair, Youth Committee of the Physician Association, Western Returned Scholars Association (WRSA)

2018–Present: Council Member, Chinese Society of Biophysics; Vice President, Sports Medicine Branch

2017–Present: Member, Chromatin Branch Committee, Chinese Society for Cell Biology

2015–Present: Standing Committee Member, Medical Cell Biology Committee, Chinese Medical Association

2012–Present: Council Member and Deputy Secretary-General of the North America Branch, Western Returned Scholars Association (Overseas-educated Scholars Association of China); Executive Vice President of the U.S.-Trained Medical Professionals Committee 

Academic Journal Appointments:

2022–Present: Executive Editor, Journal of Biological Methods

2021–Present: Guest Co-Editor-in-Chief, Frontiers in Immunology, Special Issue on "Immune Cell Lineage Reprogramming in Cancer"

2018–Present: Editorial Board Member, Chinese Science Bulletin

2018–Present: Editorial Board Member, Frontiers of Medicine in China

2012–Present: Editorial Board Member, Cancer Biology and Medicine 

Research Focus:

Infection and immunity (with a particular focus on neutralizing antibodies against SARS-CoV-2 and virus-induced signal transduction), and the molecular mechanisms of epigenetic regulation in tumor immunity and their clinical translation.

Education and Work Experience:

Sep. 1989 – Jul. 1994, Beijing Medical University (now Peking University Health Science Center), Bachelor of Medicine

Sep. 1994 – Jul. 1997, Beijing Medical University, Master of Science

Aug. 1997 – Dec. 2003, The Pennsylvania State University (USA), Ph.D., Advisor: Robert T.

Jan. 2004 – Dec. 2010, Harvard Medical School (USA), Postdoctoral Fellow Co-mentors: Charles W. M. Roberts, Stuart H. Orkin (Member of the U.S. National Academy of Sciences), Harvey Cantor (Member of the U.S. National Academy of Sciences)

Jan. 2011 – Sep. 2012, Harvard Medical School (USA), Lecturer in Pediatrics

Sep. 2012 – Aug. 2017, Vice Dean, School of Basic Medical Sciences, Tianjin Medical University; Founding Chair, Department of Cell Biology; Professor and Doctoral Supervisor

Sep. 2017 – Sep. 2021, Professor and Chair of Immunology, Capital Medical University;Doctoral Supervisor;Director, Beijing Key Laboratory of Tumor Invasion and Metastasis;Deputy Director, Department (School) of Oncology; Deputy Director, Capital Medical University Center for Pediatric Hematologic Oncology Diagnosis and Research

 Oct. 2021 – Present, Director,Professor, Researcher, and Doctoral Supervisor, the Institute of the National Infectious Disease Medical Center, Beijing Infectious Diseases Research Center, and Beijing Ditan Hospital Affiliated to Capital Medical University; Director, Beijing Key Laboratory of Tumor Invasion and Metastasis; Deputy Director, Department (School) of Oncology, Capital Medical University; Deputy Director, Capital Medical University Center for Pediatric Hematologic Oncology Diagnosis and Research 

Selected Publications:

1. Junnan Li#, Wenjuan Peng#, Yuting Zhang, Shunai Liu, Ming Han, Rui Song, Yuanyuan Zhang, Ronghua Jin*, Xi Wang*. A Comparative Study of Clinical Characteristics and COVID-19 Vaccine Effectiveness Against SARS-CoV-2 Variants Wild-Type, Alpha, Delta, and Omicron in Beijing, China. Infection and Drug Resistance. 2024,17:5147-5161. 

2. Minghang Yu#, Yang Xiong#, Pu Liang#, Danying Chen, Yuting Zhang, Huan Liu, Yuanyuan Zhang*, Xuesen Zhao*, Ronghua Jin*, and Xi Wang*. Validation of 12 Rapid Antigen Tests for the Detection of SARS-CoV-2. Journal of Biological Methods. 2024 Jan 12:11:e99010009.  

3. Bing Han#, Xu-ming Li #, Ran Li#, Wu Ning#, Yuan-yuan Zhang#, Yan-fen Tang, Ye Zhang, Long Hu, Jian-dong Li, Gang Liu, Dan Zhang, Han Xia, Xi Wang*, and Rong-meng Jiang*. Epidemiological Surveillance of Acute Respiratory Infections Based on Targeted Metagenomic Next Generation Sequencing in Beijing. Journal of Infection. 2024 May 22;89(1):106188. 

4. Yanlong Zhang#, Xuefeng Huang#, Minghang Yu#, Menghan Zhang, Li Zhao, Yong Yan*, Liyun Zhang*, Xi Wang*. The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC. Cancer Gene Therapy. 2024 Jun;31(6):917-932.

5. Danying Chen#, Xinglin Li#, Xiaohua Hao#, Yaruo Qiu#, Yanjun Song, Hui Sun, Yongmei Liu,| Juan Du, Yuanyuan Zhang, Fan Xiao, Chuan Song, Yonghong Yan, Rui Song, Xi Wang*, Xuesen Zhao*, Ronghu Jin*. Reduced neutralization and fc effector function to Omicron subvariants in sera from SARS-CoV-1 survivors after two doses of Corona Vac plus one dose subunit vaccine. Journal of Medical Virology.2023 Oct;95(10):e29136  

6. Miaoran Xia#, Bingbing Wang#, Wujianan Sun#, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, Ping Chen* , Kun Qu*, Xi Wang*，Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses. Life Science Alliance (2023) 2023 Jul 10;6(10):e202302042. 

7. Huishan Sun#, Junyu Long, Bangyou Zuo, Yiran Li, Yu Song, Minghang Yu, Ziyu Xun, Yanyu Wang, Xi Wang*, Xinting Sang*，Haitao Zhao*，Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma. BMC Cancer (2023) 23:451-468.

8. Yanlong Zhang#, Xin Zhang#, Xuefeng Huang#, Xiaomeng Tang, Menghan Zhang, Ziyi Li, Xiaopeng Hu, Min Zhang*, Xi Wang* and Yong Yan*. Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma. Stem Cell Research & Therapy.2023 Feb 1;14(1):15.

9. Minghang Yu#，Danying Chen#, Xiaomeng Tang#, Yuanyuan Zhang#, Pu Liang, Yang Xiong, Rui Li, Rui Song，Xiaoyou Chen，Xuesen Zhao*, Xi Wang*, Ronghua Jin*, Evaluation of a high-sensitivity SARS-CoV-2 antigen test on the fully automated light-initiated chemiluminescent immunoassay platform. Clinical Chemistry and Laboratory Medicine. 2023 Jan 19;61(6):1123-1130

10. Xin Zhang#, Yanlong Zhang#, Li Zhao#, Jiayu Wang, Jiaxing Li, Xi Wang*,  Min Zhang*, Xiaopeng Hu*, Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer. Frontiers in Immunology. 2022, 13:1014638. 

11. Guangxu Xuan#, Xin Zhang#, Min Zhang#, Minghang Yu, Yujie Zhou, Xiaosong He, Xiaopeng Hu*, Xi Wang*，Liangfa Liu*，NTF2 Upregulation in HNSCC: a Predictive Marker and Potential Therapeutic Target Associated With Immune Infiltration. Frontiers in Oncology. 2022 Jun 17;12:783919

12. Yunlong Cao#,*, Xiaohua Hao#, Xi Wang#, Qianhui Wu#, Rui Song, Dong Zhao, Weiliang Song, Yao Wang, Ayijiang Yisimayi, Wei Wang, Wen Zhang, Juan Du, Hongjie Yu*, Xiaoliang Sunney Xie*, Ronghua Jin*，Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine. Cell Research. 2022 Jan;32(1):107-109.

13. Minghang Yu, Ziyang Su, Xuefeng Huang, Yujie Zhou, Xulong Zhang, Bingbing Wang, Zihan Wang, Yi Liu, Nianzeng Xing*, Miaoran Xia*, Xi Wang*, Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function. Journal of Leukocyte Biology. 2021 Aug 23. 110(6):1033-1045

14. Minghang Yu #, Ziyang Su#, Xuefeng Huang and Xi Wang*, Single-cell sequencing reveals the novel role of Ezh2 in NK cell maturation and function. Frontiers in Immunology. 2021 Oct 26;12:724276. 

15. Xu Yang#, Ying Hu#, Keyan Yang#, Dongxu Wang#, Jianzhen Lin, Junyu Long, Fucun Xie, Jinzhu Mao, Jin Bian, Mei Guan, Jie Pan, Li Huo, Ke Hu, Xiaobo Yang, Yilei Mao, Xinting Sang, Jiao Zhang, Xi Wang*, Henghui Zhang*, Haitao Zhao*, Cell-free DNA copy number variations predict efficacy of immune checkpoint inhibitor-based therapy in hepatobiliary cancers. Journal for ImmunoTherapy of Cancer. 2021 Feb, 9:e001942.

16. Junyu Long#, Shan Huang#, Yi Bai#, Jinzhu Mao#, Anqiang Wang, Yu Lin, Xu Yang, Dongxu Wang, Jianzhen Lin, Jin Bian, Xiaobo Yang, Xinting Sang*, Xi Wang* and Haitao Zhao*.Transcriptional landscape of cholangiocarcinoma revealed by weighted gene coexpression network analysis.Briefings in Bioinformatics.2020.00（00）.1-17.

17. Yi Bai#, Chunlian Wei#, Yuxin Zhong#, Yamin Zhang, Junyu Long, Shan Huang, Fucun Xie, Yantao Tian, Xi Wang*, and Haitao Zhao*.Development and Validation of a Prognostic Nomogram for Gastric Cancer Based on DNA Methylation-Driven Differentially Expressed Genes.International Journal of Biological Sciences.2020.16（7）.1153-1165.

18. Jie Yin#, Jianmei W. Leavenworth#*, Yang Li, Qi Luo, Huafeng Xie, Xinhua Liu, Shan Huang, Han Yan, Zheng Fu, Liyun Y. Zhang, Litao Zhang, Junwei Hao, Xudong Wu, Xianming Deng, Charles W. M. Roberts, Stuart H. Orkin, Harvey Cantor*, Xi Wang*.Ezh2 regulates differentiation and function of natural killer cells through its histone methyltransferase activity.Proceedings of the National Academy of Sciences of the United States of America.2015.112（52）.15988-15993.

19. Xi Wang, Charles W. M. Roberts.Cancer-Fighting Smurf.Nature Medicine.2012.18（2）.204-205.

20. Xi Wang#, Miriam B.F. Werneck#, Boris G. Wilson, Hye-Jung Kim, Michael J. Kluk, Christopher S. Thom, Jonathan W. Wischhusen, Julia A. Evans, Jonathan L. Jesneck, Phuong Nguyen, Courtney G. Sansam, Harvey Cantor, and Charles W.M. Roberts.T cell receptor dependent transformation of mature memory phenotype T cells in mice.Journal of Clinical Investigation.2011.121（10）.3834-3845.

21. Boris G. Wilson#, Xi Wang#, Xiaohua Shen, Elizabeth S. McKenna, Madeleine E. Lemieux, Yoon-Jae Cho, Edward C. Koellhoffer, Scott L. Pomeroy, Stuart H. Orkin, and Charles W.M. Roberts.Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation.Cancer Cell.2010.18（4）.316-328.

22. Xi Wang, Courtney G. Sansam, Christopher S. Thom, Daniel Metzger, Julia A. Evans, Phuong T.L. Nguyen, and Charles W.M. Roberts.Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent upon activity of BRG1, the ATPase of the SWI/SNF complex.Cancer Research.2009.69（20）.8094-8101.

Awards and Honors

2023: Leading Talent in High-Level Public Health, Beijing

2023: Leading Talent of the “Phoenix Program”, Chaoyang District, Beijing

2019: Leader of High-Level Innovation Team at Municipal Universities during the 13th Five-Year Plan, Beijing

2015: Leading Talent for Scientific and Technological Innovation (Young and Middle-aged Category), Tianjin Innovation Talent Promotion Program

2012: Selected for the Tianjin “Three-Year Plan to Introduce 1,000 High-Level Talents” Program

Contact Information

Email: xiwang@ccmu.edu.cn

Work Phone: 010-84322621