王玺

研究员

博士生导师（球盟会qmh网页版登录）

硕士生导师（球盟会qmh网页版登录）

学术组织任职：

2023年-至今  北京慢性病防治与健康教育研究会感染性疾病专业委员会  主任委员

2023年-至今  中国免疫学会基础免疫分会  常务委员

2022年-至今  中国会展经济研究会会展防疫工作委员会  主任委员

2022年-至今  北京中西医结合学会感染专业委员会  副主任委员

2020年-至今  中国人体健康科技促进会泌尿男科生殖系肿瘤专业委员会  常务委员

2019年-至今  北京市免疫学会  常务理事

2018年-至今  欧美同学会医师协会青年委员会  副主任委员

2018年-至今  中国生物物理学会理事兼体育医学分会  副会长

2017年-至今  中国细胞生物学会染色质分会委员会  委员

2015年-至今  中华医学会医学细胞生物委员会  常务委员

2012年-至今  欧美同学会-留学归国人员联谊会北美分会理事兼副秘书长兼留美医学  委员会  常务副会长

学术期刊任职：

2022年-至今 《Journal of Biological Methods》  Executive Editor执行主编

2021年-至今 《Frontiers in Immunology》Special Issue on Research Topic "Immune Cell  Lineage Reprogramming in Cancer"   特邀共同主编

2018年--至今 《科学通报》  编委

2018年-至今  《中国医学前沿杂志》  编委

2012年-至今  《Cancer Biology and Medicine》  编委

研究方向：

感染免疫（尤其是新冠病毒的中和抗体、病毒感染后激发的信号转导）、肿瘤免疫的表观遗传调控分子机理及其临床转化

教育工作经历：

1989/09-1994/07，北京医科大学（北京大学医学部），医学学士

1994/09-1997/07，北京医科大学，理学硕士。

1997/08-2003/12，美国宾夕法尼亚州立大学，博士，导师：Robert T. Simpson

2004/01-2010/12，美国哈佛大学医学院，博士后，合作导师：Charles W. M. Roberts Stuart H. Orkin（美国科学院院士），Harvey Cantor（美国科学院院士）

2011/01-2012/09，美国哈佛大学医学院，儿科，讲师

2012/09-2017/08，天津医科大学基础医学院副院长、细胞生物学系创系主任、教授、博士生导师

2017.09-2021.09，球盟会qmh网页版登录，免疫学教授、系主任、博士生导师；北京市肿瘤侵袭和转移重点实验室主任；肿瘤学系（院）副主任;球盟会qmh网页版登录儿童血液肿瘤诊疗与研究中心副主任

2021.10-至今，国家传染病医学中心，北京市感染性疾病研究中心，球盟会qmh网页版登录附属地坛医院研究所，所长、教授、研究员、博士生导师；北京肿瘤侵袭和转移重点实验室主任；球盟会qmh网页版登录肿瘤学系（院）副主任;球盟会qmh网页版登录儿童血液肿瘤诊疗与研究中心副主任

代表性论文：

1. Junnan Li#, Wenjuan Peng#, Yuting Zhang, Shunai Liu, Ming Han, Rui Song, Yuanyuan Zhang, Ronghua Jin*, Xi Wang*. A Comparative Study of Clinical Characteristics and COVID-19 Vaccine Effectiveness Against SARS-CoV-2 Variants Wild-Type, Alpha, Delta, and Omicron in Beijing, China. Infection and Drug Resistance. 2024,17:5147-5161. 

2. Minghang Yu#, Yang Xiong#, Pu Liang#, Danying Chen, Yuting Zhang, Huan Liu, Yuanyuan Zhang*, Xuesen Zhao*, Ronghua Jin*, and Xi Wang*. Validation of 12 Rapid Antigen Tests for the Detection of SARS-CoV-2. Journal of Biological Methods. 2024 Jan 12:11:e99010009.  

3. Bing Han#, Xu-ming Li #, Ran Li#, Wu Ning#, Yuan-yuan Zhang#, Yan-fen Tang, Ye Zhang, Long Hu, Jian-dong Li, Gang Liu, Dan Zhang, Han Xia, Xi Wang*, and Rong-meng Jiang*. Epidemiological Surveillance of Acute Respiratory Infections Based on Targeted Metagenomic Next Generation Sequencing in Beijing. Journal of Infection. 2024 May 22;89(1):106188. 

4. Yanlong Zhang#, Xuefeng Huang#, Minghang Yu#, Menghan Zhang, Li Zhao, Yong Yan*, Liyun Zhang*, Xi Wang*. The integrate profiling of single-cell and spatial transcriptome RNA-seq reveals tumor heterogeneity, therapeutic targets, and prognostic subtypes in ccRCC. Cancer Gene Therapy. 2024 Jun;31(6):917-932.

5. Danying Chen#, Xinglin Li#, Xiaohua Hao#, Yaruo Qiu#, Yanjun Song, Hui Sun, Yongmei Liu,| Juan Du, Yuanyuan Zhang, Fan Xiao, Chuan Song, Yonghong Yan, Rui Song, Xi Wang*, Xuesen Zhao*, Ronghu Jin*. Reduced neutralization and fc effector function to Omicron subvariants in sera from SARS-CoV-1 survivors after two doses of Corona Vac plus one dose subunit vaccine. Journal of Medical Virology.2023 Oct;95(10):e29136  

6. Miaoran Xia#, Bingbing Wang#, Wujianan Sun#, Dengyu Ji, Hang Zhou, Xuefeng Huang, Minghang Yu, Ziyang Su, Ping Chen* , Kun Qu*, Xi Wang*，Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses. Life Science Alliance (2023) 2023 Jul 10;6(10):e202302042. 

7. Huishan Sun#, Junyu Long, Bangyou Zuo, Yiran Li, Yu Song, Minghang Yu, Ziyu Xun, Yanyu Wang, Xi Wang*, Xinting Sang*，Haitao Zhao*，Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma. BMC Cancer (2023) 23:451-468.

8. Yanlong Zhang#, Xin Zhang#, Xuefeng Huang#, Xiaomeng Tang, Menghan Zhang, Ziyi Li, Xiaopeng Hu, Min Zhang*, Xi Wang* and Yong Yan*. Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma. Stem Cell Research & Therapy.2023 Feb 1;14(1):15.

9. Minghang Yu#，Danying Chen#, Xiaomeng Tang#, Yuanyuan Zhang#, Pu Liang, Yang Xiong, Rui Li, Rui Song，Xiaoyou Chen，Xuesen Zhao*, Xi Wang*, Ronghua Jin*, Evaluation of a high-sensitivity SARS-CoV-2 antigen test on the fully automated light-initiated chemiluminescent immunoassay platform. Clinical Chemistry and Laboratory Medicine. 2023 Jan 19;61(6):1123-1130

10. Xin Zhang#, Yanlong Zhang#, Li Zhao#, Jiayu Wang, Jiaxing Li, Xi Wang*,  Min Zhang*, Xiaopeng Hu*, Exploitation of tumor antigens and construction of immune subtype classifier for mRNA vaccine development in bladder cancer. Frontiers in Immunology. 2022, 13:1014638. 

11. Guangxu Xuan#, Xin Zhang#, Min Zhang#, Minghang Yu, Yujie Zhou, Xiaosong He, Xiaopeng Hu*, Xi Wang*，Liangfa Liu*，NTF2 Upregulation in HNSCC: a Predictive Marker and Potential Therapeutic Target Associated With Immune Infiltration. Frontiers in Oncology. 2022 Jun 17;12:783919

12. Yunlong Cao#,*, Xiaohua Hao#, Xi Wang#, Qianhui Wu#, Rui Song, Dong Zhao, Weiliang Song, Yao Wang, Ayijiang Yisimayi, Wei Wang, Wen Zhang, Juan Du, Hongjie Yu*, Xiaoliang Sunney Xie*, Ronghua Jin*，Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine. Cell Research. 2022 Jan;32(1):107-109.

13. Minghang Yu, Ziyang Su, Xuefeng Huang, Yujie Zhou, Xulong Zhang, Bingbing Wang, Zihan Wang, Yi Liu, Nianzeng Xing*, Miaoran Xia*, Xi Wang*, Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function. Journal of Leukocyte Biology. 2021 Aug 23. 110(6):1033-1045

14. Minghang Yu #, Ziyang Su#, Xuefeng Huang and Xi Wang*, Single-cell sequencing reveals the novel role of Ezh2 in NK cell maturation and function. Frontiers in Immunology. 2021 Oct 26;12:724276. 

15. Xu Yang#, Ying Hu#, Keyan Yang#, Dongxu Wang#, Jianzhen Lin, Junyu Long, Fucun Xie, Jinzhu Mao, Jin Bian, Mei Guan, Jie Pan, Li Huo, Ke Hu, Xiaobo Yang, Yilei Mao, Xinting Sang, Jiao Zhang, Xi Wang*, Henghui Zhang*, Haitao Zhao*, Cell-free DNA copy number variations predict efficacy of immune checkpoint inhibitor-based therapy in hepatobiliary cancers. Journal for ImmunoTherapy of Cancer. 2021 Feb, 9:e001942.

16. Junyu Long#, Shan Huang#, Yi Bai#, Jinzhu Mao#, Anqiang Wang, Yu Lin, Xu Yang, Dongxu Wang, Jianzhen Lin, Jin Bian, Xiaobo Yang, Xinting Sang*, Xi Wang* and Haitao Zhao*.Transcriptional landscape of cholangiocarcinoma revealed by weighted gene coexpression network analysis.Briefings in Bioinformatics.2020.00（00）.1-17.

17. Yi Bai#, Chunlian Wei#, Yuxin Zhong#, Yamin Zhang, Junyu Long, Shan Huang, Fucun Xie, Yantao Tian, Xi Wang*, and Haitao Zhao*.Development and Validation of a Prognostic Nomogram for Gastric Cancer Based on DNA Methylation-Driven Differentially Expressed Genes.International Journal of Biological Sciences.2020.16（7）.1153-1165.

18. Jie Yin#, Jianmei W. Leavenworth#*, Yang Li, Qi Luo, Huafeng Xie, Xinhua Liu, Shan Huang, Han Yan, Zheng Fu, Liyun Y. Zhang, Litao Zhang, Junwei Hao, Xudong Wu, Xianming Deng, Charles W. M. Roberts, Stuart H. Orkin, Harvey Cantor*, Xi Wang*.Ezh2 regulates differentiation and function of natural killer cells through its histone methyltransferase activity.Proceedings of the National Academy of Sciences of the United States of America.2015.112（52）.15988-15993.

19. Xi Wang, Charles W. M. Roberts.Cancer-Fighting Smurf.Nature Medicine.2012.18（2）.204-205.

20. Xi Wang#, Miriam B.F. Werneck#, Boris G. Wilson, Hye-Jung Kim, Michael J. Kluk, Christopher S. Thom, Jonathan W. Wischhusen, Julia A. Evans, Jonathan L. Jesneck, Phuong Nguyen, Courtney G. Sansam, Harvey Cantor, and Charles W.M. Roberts.T cell receptor dependent transformation of mature memory phenotype T cells in mice.Journal of Clinical Investigation.2011.121（10）.3834-3845.

21. Boris G. Wilson#, Xi Wang#, Xiaohua Shen, Elizabeth S. McKenna, Madeleine E. Lemieux, Yoon-Jae Cho, Edward C. Koellhoffer, Scott L. Pomeroy, Stuart H. Orkin, and Charles W.M. Roberts.Epigenetic antagonism between Polycomb and SWI/SNF complexes during oncogenic transformation.Cancer Cell.2010.18（4）.316-328.

22. Xi Wang, Courtney G. Sansam, Christopher S. Thom, Daniel Metzger, Julia A. Evans, Phuong T.L. Nguyen, and Charles W.M. Roberts.Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent upon activity of BRG1, the ATPase of the SWI/SNF complex.Cancer Research.2009.69（20）.8094-8101.

获奖情况：

2023年  北京市高层次公共卫生领军人才

2023年  北京市朝阳区凤凰计划领军人才

2019年  “十三五”时期北京市属高校高水平创新团队领头人

2015年  天津市创新人才推进计划中青年科技创新领军人才

2012年  天津市“三年引进千名高级人才”计划入选者

联系方式：

电子邮箱：xiwang@ccmu.edu.cn

工作电话：010-84322621