孔雅娴

研究员，教授

博士生导师（球盟会qmh网页版登录、北京大学医学部） 

学术组织任职：

中国人体健康科技促进会免疫缺陷监测与转化专委会常务委员

中国防痨协会人兽共患结核病专委会常务委员

中国研究型医院学会肝病专委会青年委员

北京慢性病防治与健康教育研究会感染性疾病专业委员会常务委员

北京市预防医学会卫生检验与实验医学专业委员会委员

学术期刊任职：

Infectious Disease & Immunity 青年编委

研究方向：

感染与衰老免疫

教育工作经历：

1999.09-2004.07  北京大学医学部，临床医学专业，医学学士

2004.09-2009.07  北京大学医学部，干细胞中心，博士，细胞生物学

2009.08-2014.10  球盟会qmh网页版登录，传染病研究所，助理研究员

2014.12-2015.08  美国宾夕法尼亚州立大学，访问学者

2014.11-2019.04  球盟会qmh网页版登录，传染病研究所；副研究员

2017.12-2018.12  美国宾夕法尼亚州立大学，访问学者

2019.12-至今   球盟会qmh网页版登录，研究员

2023.05-至今   球盟会qmh网页版登录，教授

代表性论文：

1. Zhang R#, Mu Y#, Zhang M#, Wu H, Xu Y, Zhao C, Liu Z, Lin L, Zhang W, Kong Y#, Chen Z*. Lactate Dehydrogenase/Albumin to Urea Ratio: A Novel Prognostic Indicator for Adverse Outcomes in Patients With Severe Fever With Thrombocytopenia Syndrome. J Med Virol. 2025 Jun;97(6):e70428.

2. Zhang L#, Zhao H#, Chen N#, Wang X#, Du J, Wang D, Liu Y, Wei Y, Zhang M, Deng M, Jiang M, Kong Y*. Increased frequency of Foxp3+CD8+T cells is associated with disease progression during HIV infection. AIDS. 2025 Jul 1;39(8):946-956.

3. Chen N#, Zhang L#, Wang X#, He Z, Wang D, Du J, Deng M, Zhang M, Jiang M, Wei Y, Zhao M, Liu Y, Wang X, Zhao H*, Kong Y*. Increased levels of Foxp3+CD4+NKT-like cells are associated with HIV disease progression. Clin Immunol. 2025 May 27;278:110533.

4. Wang X, Kong Y*. Advancing mechanistic understanding of post-acute sequelae of Ebola virus disease. Lancet Microbe. 2025 Apr 18:101139. doi: 10.1016/j.lanmic.

5. Wang X, Kong Y*. Crucial analysis of Nef-mediated MHC-I modulation in the maintenance of the HIV-1 reservoir. Lancet Microbe. 2025 Apr 1:101133. doi: 10.1016/j.lanmic.2025.101133.

6. Xie Y, Yan F, Liu X, Yu L, Yan H, Shang Z, Kong Y*, Yang Z*. FoxO1 as a Hub in Immunosenescence Induced by Hepatocellular Carcinoma and the Effect of Yangyin Fuzheng Jiedu Prescription. Drug Des Devel Ther. 2025 Mar 5;19:1543-1560.

7. Xie YQ, Yan FN, Yu LH, Yan HW, Kong YX*, Yang ZY*. Mechanism of Shashen-Maidong herb pair in treating hepatocellular carcinoma using network pharmacology and experimental validation. J Ethnopharmacol. 2025 Jan 30;337(Pt 3):118954.

8. Wang X, Wei Y, He Z, Wang D, Zhang L, Du J, Zhang M, Jiang M, Chen N, Deng M, Li B, Song C, Chen D, Liu H, Xiao J, Liang H, Zhao H, Kong Y*. CD70-induced Differentiation of Proinflammatory Th1/17/22/GM Lymphocytes Associated with Disease Progression and Immune Reconstitution During HIV Infection. Emerging Microbes & Infections. 2023 Dec;12(2):2271068.

9. Wang X#, Wang D#, Du J#, Wei Y, Song R, Wang B, Qiu S, Li B, Zhang L, Zeng Y, Zhao H, Kong Y*. High Levels of CD244 Rather Than CD160 Associate With CD8+ T-Cell Aging. Front Immunol. 2022 Mar 21;13:853522.

10. Kong Y#, Wang Y#, Wu X#, Han J, Li G, Hua M, Han K, Zhang H*, Li A*, Zeng H*. Storm of soluble immune checkpoints associated with disease severity of COVID-19. Signal Transduct Target Ther. 2020 Sep 7;5(1):192.

11. Kong Y#*, Han J#, Wu X#, Zeng H, Liu J*, Zhang H*. VEGF-D: a novel biomarker for detection of COVID-19 progression. Version 2. Crit Care. 2020 Jun 23;24(1):373.

12. Liu X, Li M, Wang X, Dang Z, Jiang Y, Wang X, Kong Y*, Yang Z*. PD-1+ TIGIT+ CD8+ T cells are associated with pathogenesis and progression of patients with hepatitis B virus-related hepatocellular carcinoma. Cancer Immunol Immunother. 2019 Dec;68(12):2041-2054.

13. Kong Y, Jia B, Zhao C, Claxton DF, Sharma A, Annageldiyev C, Fotos JS, Zeng H, Paulson RF, Prabhu KS, Zheng H*. Downregulation of CD73 Associates with T cell Exhaustion in AML Patients. Journal of Hematology & Oncology. 2019 Apr 24;12(1):40.

14. Song Y, Wang B, Song R, Hao Y, Wang D, Li Y, Jiang Y, Xu L, Ma Y, Zheng H, Kong Y*, Zeng H*. T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenescence. Aging Cell.2018,17(2):12716.

15. Zhu L#, Kong Y #, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H, Zheng H. Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. J Hematol Oncol. 2017 Jun 19;10(1):124.

16. Kong Y, Zhu L, Schell TD, Zhang J, Claxton DF, Ehmann WC, Rybka W, George MR, Zeng H*, Zheng H*. T-cell Immunoglobulin and ITIM Domain (TIGIT) Associates with CD8+ T cell Exhaustion and Poor Clinical Outcome in AML Patients. Clin Cancer Res. 2016 Jun 15;22(12):3057-66.

17. Kong Y, Li Y, Zhang W, Yuan S, Winkler R, Krohnert U, Han J, Lin T, Zhou Y, Miao P, Wang B, Zhang J, Yu Z, Zhang Y, Kosan C, Zeng H. Sepsis-Induced Thymic Atrophy is Associated with Defects in Early Lymphopoiesis. Stem Cells. 2016;34(12):2902-2915.

18. Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Zhu L, Zeng H, Schell TD, Zheng H*. PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer J. 2015 Jul 31;5:e330.

人才称号：

2025年：入选北京市朝阳区最美科技工作者

2023年：入选北京市医管中心“登峰”人才计划

2023年：入选北京市卫健委高层次公共卫生技术人才

2021年：获得北京市杰青科学基金资助

2021年：入选北京市朝阳区“凤凰人才”计划

2016年：入选北京市科技新星

2016年：入选北京市医管局“青苗”人才

联系方式：

电子邮箱：kongyaxian@ccmu.edu.cn

工作电话：010-84322620